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Glioblastoma multiforme
Glioblastoma multiforme (GBM), also known as glioblastoma and grade IV astrocytoma, is the most common and most aggressive malignant primary brain tumor. It involves glial cells and accounting for 52% of all brain tissue tumor cases and 20% of all tumors inside the skull. GBM is a rare disease, with a rate of 2–3 cases per 100,000 person life-years in Europe and North America. About 50% of the people diagnosed with GBM die within one year, while 90% within three years.
Treatment can involve chemotherapy, radiation, and surgery. Median survival with standard-of-care radiation and chemotherapy with temozolomide is 15 months. Median survival without treatment is 4½ months. Although no randomized controlled trials have been done, surgery remains the standard of care.
==Signs and symptoms==
(詳細はseizure, nausea and vomiting, headache, memory loss, and hemiparesis, the single most prevalent symptom is a progressive memory, personality, or neurological deficit due to temporal and frontal lobe involvement. The kind of symptoms produced depends highly on the location of the tumor, more so than on its pathological properties. The tumor can start producing symptoms quickly, but occasionally is an asymptomatic condition until it reaches an enormous size.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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